5-ALA derivative-mediated photoinactivation of Propionibacterium acnes

5-Aminolevulinic acid (5-ALA)-mediated photodynamic therapy (PDT) combines the administration 5-ALA which is selectively converted into the photosensitizer protoporphyrin IX (PpIX) in diseased cells, irradiation with light, and oxygen . The concerted action of these elements produces highly reactive oxygen species which, in turn, destroy cells of high PpIX content. Due to the unfavourable local bioavailability of 5-ALA, more lipophilic derivatives have been proposed, and methyl aminolevulinate (MAL) and hexyl aminolevulinate (HAL) recently gained marketing authorization

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5-ALA derivative-mediated photoinactivation of Propionibacterium acnes

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