Interleukin-1A +4845(G>T) polymorphism is a factor predisposing to acne vulgaris

Acne vulgaris is a common chronic inflammatory skin disease of multifactorial origin. The aim of this study was to clarify whether known polymorphisms of the interleukin-1A (IL1A) and IL1RN genes play a role in the pathogenesis of acne vulgaris. A positive association was found between the minor T allele of the IL1A +4845(G> T) single nucleotide polymorphism (SNP) and acne, whereas no association was found with respect to any alleles of the variable number of tandem repeats (VNTR) polymorphism of the IL1RN gene.

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Interleukin-1A +4845(G>T) polymorphism is a factor predisposing to acne vulgaris

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